Thursday, July 16, 2020

African/African-American and Non-Finnish European populations more susceptible to COVID-19

According to New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis published on 15 July 2020 in BMC Medicine by Cleveland Clinic researchers,

"the distribution of deleterious variants in ACE2 differs among 9 populations in gnomAD (v3). Specifically, 39% (24/61) and 54% (33/61) of deleterious variants in ACE2 occur in African/African-American (AFR) and Non-Finnish European (EUR) populations, respectively (Fig. 1b). Prevalence of deleterious variants among Latino/Admixed American (AMR), East Asian (EAS), Finnish (FIN), and South Asian (SAS) populations is 2–10%, while Amish (AMI) and Ashkenazi Jewish (ASJ) populations do not appear to carry such variants in ACE2 coding regions"

If needed, Figure 1b can be viewed here. This research of course mean Latinos or Asians can take it easy when it comes to prevention. In fact, the outbreaks in Brazil and India appear to contradict this research. But this research is about genetic susceptibility, not considering the social factors that may play a greater role, such as whether people wear face masks and keep social distancing.